Synthesis of New Solid Forms of Bumetanide and Their Characterization - Free Essay Example

Sample details Pages: 6 Words: 1843 Downloads: 6 Date added: 2019/03/18 Category Analytics Essay Level High school Tags: Characterization Essay Did you like this example? 1. INTRODUCTION Bumetanide (BUM) is a loop diuretic of the sulfamyl category, (3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid) most often used to treat heart failure. Most often used in the people whom high dose of furosemide or other diuretics are ineffective. Don’t waste time! Our writers will create an original "Synthesis of New Solid Forms of Bumetanide and Their Characterization" essay for you Create order The main differences between bumetanide and furosemide are the bioavailability and potency. Mostly 60 percent of furosemide is absorbed in the intestine, and these are substantial inter and intra-individual differences in the bioavailability (range 10-90%). About 80 percent of bumetanide is absorbed, and these absorption does not change when it is taken with food. It is said to be a more diuretics, meaning that the predictable absorption is reflected in a more predictable effect. Bumetanide drug are 40 times more potent than furosemide for patients with normal renal function. It is sometimes used for weight loss because, use as a diuretic, and removes water from body. The study of solid state chemistry of pharmaceutical solid focuses on all disciplines right from drug discovery to successful marketing. A clear understanding of the molecular structure can lead to a better design and control of the drug performance. Moreover, interest in the subject of pharmaceutical solids stems in th e part from FDAs substance guideline that states appropriate analytical procedures to be used to detect polymorphic, cocrystals, hydrated or amorphous forms of the drug substance. Solid forms are usually more stable than liquid counterpart. The main factors which affect the oral route absorption are aqueous solubility, physical/chemical stability, and permeability. The fundamental parameters, i.e. aqueous solubility and gastrointestinal permeability which define oral drug absorption are used as the basis for the BCS classification scheme. These biopharmaceutical classes are defined as below figure.-01 Solubility and permeability parameters defined by FDA and according to it, A drug substance is considered highly soluble when the highest strength is soluble in 250 mL or less of aqueous media within the pH range of 1- 6.8 at 37 ? ± 1? °C and A drug substance is considered to be highly permeable when the systemic Bioavailability or the extent of absorption in the humans is determin ed to be 85 percent or more in to the administered dose based on a mass balance determination (along with evidence showing stability of the drug in the GI tract ) or in comparison to an intravenous reference dose. 1 Bumetanide is the diuretics agent, belongs to BCS class II. A survey by Lin et al.3 revealed that almost 40% of marketed medicines and 90% of emerging new chemical entities suffer from poor solubility which allows them to be eliminated from the gastrointestinal tract before they get completely dissolved and absorbed into the blood circulation, thus results in low bioavailability, less potency, and higher dose strength. For these classes of drugs, higher dose strength would be required to ensure therapeutic concentration in blood but it may lead to adverse or toxic effects on the recipients body. Thus, new solid forms of the API, which may overcome these problems without affecting the chemical nature of it, greatly reduces the risk, time and cost in development. 1.1. Types of solids forms: Longer range order shorter range order Crystalline Amorphous Liquid crystalline Single component multiple component Ionic non-ionic Polymorphs Salt Molecular adduct Solvates/Hydrates Cocrystal Solid is one of the four fundamental states of matter (the others are liquid, gas, and plasma). Solids molecules are closely packed. These are characterized by structural rigidity and resistance to changes in the shape or volume. Unlike a liquid, or a solid object does not flow to take on the shape of its container, nor does it expand to fill the entire volume available to it like a gas does. All atoms in a solid are tightly bound to each other, either in a regular geometric lattice (crystalline solids, which include metals and ordinary ice) or irregularly (an amorphous solid such as common window glass). Solids cannot be compressed within the little pressure whereas gases can be compressed within little pressure because in gases molecules are loosely packed. In mate rials science, polymorphism is the ability in a solid material to exist in more than one form or crystal structure. Polymorphism can potentially be found in the any crystalline material including polymers, minerals, and metals, and is compare to allotropy, which refers to chemical elements. Most pharmaceutical molecules are polymorphic. Polymorphism is an ability of a chemical compound to crystallize depending on the crystallization conditions in different crystal structures alias polymorphs. Molecules in the crystal structure of a Polymorphs are bonded by weak interactions (H-bridges, Van-der Waals forces, - interactions). Amorphous materials have an internal structure made up of inter-connected structural blocks. This blocks can be similar to the basic structural units found in the corresponding crystalline phase of the same compound. Whether a material is liquid or solid depends upon the primarily connectivity between its elementary building blocks so that solids are characteriz ed by a high degree of connectivity whereas structural blocks in fluids have lower connectivity. In pharma industry, the amorphous drugs are shown to have higher bioavailability than their crystalline counter parts due to the high solubility of amorphous phase. Moreover, certain compounds can undergoes precipitation in their amorphous form in vivo, and they can decrease each others bioavailability if administered together. 1.2. Crystal Engineering: Crystal engineering developed over the past 65 years as a natural outcome of the interplay between crystallography and chemistry. Chemistry deals with the molecules while crystallography deals with regularly arranged molecules. The term Crystal engineering was coined by pepinsky in the year 1955. According to pepinsky, crystallization of organic ions with a metal-containing complex ion of suitable sizes, charges and solubilitys result in structures with cells and symmetries determined chiefly by packing of complex ions. These cells and symmetries are to be good extent controllable; hence crystals with advantageous properties can be engineered. Crystal engineering is an interdisciplinary area in chemistry, which bridges, chemistry and crystallography. In the present decade, research is mainly focused on controlling the directionality and strength of intermolecular interaction in the design of molecular crystals. A. I. Kitagorodskii gave the definition of the molecular crystal which state that, within a molecular crystal, it is possible to identify groups of atoms such that for every atom of a group, at least one inter atomic distance within this group is significantly shorter than the smallest inter atomic distance to an atom in another group. 4 He invoked a question, molecule to crystal, he stated that packing of molecular solids was largely governed by considerations of size and shape, the so-called principle of packing. Today, X-ray crystallography is a matured science and has a far-reaching impact on material characterization. The structural insights obtained from crystal structure analysis led to unprecedented developments in electronic devices, mineralogy, geosciences, material science, and pharmaceuticals. Detailed knowledge of accurate structural information of active pharmaceutical ingredients (APIs) is a prerequisite for rational drug design and synthesis of new chemical entities for the development of new medicines. As research progressed with time, the focus shifted to multicomponent molecular crystals (cocrystals). The knowledge obtained from the analysis of the crystal structures is used in the selection of conformer for cocrystal design. A successful cocrystal synthesis requires the understanding of supramol ecular synthons that occur most frequently between the functional groups of cocrystals components. Hence, the design of cocrystals for a given molecule starts with analyzing the functional groups available on that molecule and finding complementary functional groups which would likely form predictable supramolecular synthons. Thus, the conformer selection in a cocrystal design strategy reinforces a more significant role of the knowledge of intermolecular interactions which is often drawn from X-ray crystal structure analysis. In a crystal, molecules are associated with a specific pattern of non-covalent interactions such as hydrogen bonds, halogen bonds,5 and -stacking. Over the past century, single-crystal X-ray diffraction has proven to be an important tool for unambiguous determination of crystal structure, and thus, assisted in ground-breaking analysis of material properties. Concerning cocrystals, structural characterization (a) establishes the reliability of cocrystal design s trategy, (b) reveals hydrogen bind preferences of the functional groups, and (c) provides insights into structure-property correlation. Crystal engineering is a concept of great application and scope. Presently, it focuses on more practical applications such as pharmaceutical cocrystals and high energy materials, etc. Fig.1. Crystal engineering involves modification Of the crystal packing of a solid material by changing the intermolecular interactions.6 1.3. Non-covalent Interactions: Non-covalent interactions are ubiquitous in chemistry and are the primary source of stability for many molecular complexes in biological, pharmacological. Chemical, physical, and material sciences, etc. while traditional chemistry focuses on the covalent bond, crystal engineering and supramolecular chemistry exploit the non-covalent interactions which hold molecules together in a crystal lattice. These forces include hydrogen bonding, metal coordination, hydrophobic forces, Van-der Waals forces, - inte ractions and electrostatic effect. 1.4. Hydrogen Bond (strong and weak): Hydrogen bonds are electrostatic and play an essential role in stabilizing the molecular aggregates. Nernst first introduced the phenomenon of hydrogen bong formation in 1891.7 Bernel and huggins proposed the term Hydrogen bond in the year of 1935-36.8 In the year of 1939, Linus pauling defined the hydrogen bond as under certain conditions, an atom of hydrogen is attracted by rather strong forces to two atom instead of only one, so that it may be considered to acting as a bond between them. The more elaborative and expanded definitions were given by many scientists as the increased interest of research in this field, which include Pimentel and McClellan (1960),9 IUPAC stated that the hydrogen bond (designated as D-HA, where acceptor A and donor D are electronegative atoms) is an attractive interaction between a hydrogen atom from a fragment or molecule D-H in which D is more electronegative is that H, and an atom or a group of atoms A, in the sam e or different molecule where there is evidence of bond formation. Depending on the nature of the donor and acceptor atoms which constitute the bond, their geometry, and environment, the energy of a hydrogen bond can vary between 1 and 40 kcal/mol. The hydrogen bond is not a simple interaction but a complex conglomerate of at least four component interaction types: electrostatics (acid/base), polarization (hard/soft), van der Waals (dispersion/repulsion) and covalency (charge-transfer). It is neither a strong van der Waals interaction nor a weak covalent bond. It is not even a strong directional dipole-dipole interaction. For geometrical parameters of hydrogen bond see figure-2. This interaction characterized through X-ray diffraction, neutron diffraction, NMR, FT-IR and RAMAN spectroscopes. Three types of hydrogen bond exist very strong, strong and weak(table 1.1). 11 Because of this dual nature (very strong/weak), it attract many scientists all over the world. Hydrogen bonds are electrostatic interactions, but the proportions of electrostatic character can vary. A more expanded proposed definition of a hydrogen bond is as any interaction X-HA with a shallower energy/distance dependence should be termed as a hydrogen bond. Table No.01: Classification of Jeffrey11 for strong, moderate, and weak hydrogen bonds (the numerical data are guiding values only) Strong Moderate Weak interaction type strongly covalent mostly electrostatic electrostatic/dispersive bond length [?†¦] HA 1.2-1.5 1.5-2.2 2.2 lengthening of X-H 0.08-0.25 0.02-0.08 130 90 bond energy [kcal/mol] 15-40 4-15

Mgt 450 - Week 5 Final Paper - 4034 Words

Acting Strategic Growth Plan For DTAG Student Name MGT450: Strategic Planning for Organizations Instructor: Carol Hooper-Boyd August 12, 2013 Acting Strategic Growth Plan For DTAG Strategic management is very important in the business world. It is the way leaders or organizations steer their company to success over both the short- and long-term. It encompasses a host of decisions that range from what the company will produce, to how it will compete in its industry, to how it will grow over time. At the heart of strategic management is strategic planning. In this paper, the company Dollar Thrifty Automotive Group, Inc., will be analyzed as a strategic plan is presented in regards to growing the business over the next three years.†¦show more content†¦With the purchase of DTAG by Hertz, it effectively changes this to just three major organizations and should give Hertz Dollar Thrifty the edge in market share since both were major players on their own before the acquisition. As a current employee for the organization, I have a lot of insight as to what makes the company tick as well as where it may fall short in servicing its customers and employees. Due to the high level of competition in the car rental industry, which is predominantly based on price, there is not a lot of distinction between competitors. How DTAG tries to differentiate itself from the industry, though, is by trying to facilitate a smooth transaction for its customers with excellent customer service from all aspects of the rental transaction. An example of such a smooth transaction is the fact that at many locations (including the one that I work at), the rental agents do not assign a vehicle at the rental counter. Once the rental agreement is set up and a car class is selected, the customer goes out to the parking lot and chooses any vehicle they like from the selected car class. Also, if the customer would like to, they could choose to upgrade to another car class with the lot agents that are outside. This effectively keeps the lines at the rental counter moving while also putting some control in the hands of the customer. It also streamlines the rental process to allow the rental agents to take care of moreShow MoreRelatedIntroduction to Materials Management169665 Words   |  679 PagesEducation Singapore Pte. Ltd. Pearson Education Canada, Ltd. Pearson Education—Japan Pearson Education Australia Pty. Limited Pearson Education North Asia Ltd. Pearson Educacià ³n de Mexico, S.A. de C.V. Pearson Education Malaysia Pte. Ltd. 10 9 8 7 6 5 4 3 2 1 ISBN-13: 978-0-13-233761-8 ISBN-10: 0-13-233761-4 From the Library of Girro@qq.com PREFACE Introduction to Materials Management is an introductory text written for students in community colleges and universities. It is used in technicalRead MoreAccounting Systems, Internal Controls, and Ethics28179 Words   |  113 Pages Accounting Information Systems ACCOUNTING SYSTEMS, INTERNAL CONTROLS, AND ETHICS Prepared for the course team by Vimlesh B. Narayan Unit 1 Contents Unit 1 Contents 2 Concept Map 3 Learning Outcomes 4 1.1 Introduction 5 1.2 Accounting System Design 6 System Objectives and Design Factors 6 Designing the System 8 1.3 Internal Control Systems 17 Objectives of Internal Control Systems 17 Structure of Internal Control Systems 18 Why You Should Consider the ComponentsRead MoreService Quality and Customer Satisfaction in Public and Private Universities in Tanzania22790 Words   |  92 PagesAcknowledgement iii Dedication iv Abstract v Table of Contents vi LIST OF TABLES ix LIST OF FIGURES x LIST OF ABBREVIATIONS xi CHAPTER ONE 1 INTRODUCTION 1 1.1 Background information to the problem 1 1.2 Statement of the Problem 5 1.3 Objectives of the study 6 1.4 Research Questions 7 1.5 Research hypothesis 7 1.6 Significance of the Study 7 1.7 Limitations of the study 8 1.8 Organization of dissertation 9 CHAPTER TWO 10 LITERATURE REVIEW 10 2.1 IntroductionRead More THE IMPACT OF KNOWLEDGE MANAGEMENT PRACTICES IN IMPROVING STUDENT LEARNING OUTCOMES65118 Words   |  261 Pages114 vii Chapter 4 Data Analysis and Findings Introduction Survey Administration Data Coding Response Analysis Construct Analysis Hypothesis Testing – Main Effect Summary of Main Effect Hypothesis Testing 120 120 120 122 122 125 147 168 Chapter 5 Results, Conclusions, and Recommendations Introduction Summary of the Study Discussion of the Results Conclusions Limitations of the Study Recommendations for Future Research References Appendix I: Information Quality Questionnaire Items Appendix II:

Comparing Brave New World and Blade Runner - 1324 Words

Human relationships, and humanitys understanding of the wild, are shaped and reflected in Blade Runner, by Ridley Scott, and in Brave New World (Aldous Huxley) through their composers use of the contrast between true nature and the wild. The human relationship with the wild is tenuous, and this is shown within both texts. More often than not, nature is understood simply as a force to be dominated, controlled or exploited for the benefit of humanity. The new wild is one created by human society however, although developed and sustained by the characters, the wild seems to control and manipulate humanity, rather than the reverse. In Blade Runner and in Brave New World, the nature of happiness and freedom is one of the most recurrent†¦show more content†¦In contrast to this, the discovery by Rachael of her true identity, a replicant, destroys the illusion of happiness her place in society had given her; Rachael: Im not in the business. ...I am the business. But this allowed her to discover a semblance of freedom. The failure of the replicants to truly become a part of human society is that they are too much a part of the new wild, perfect in the face of humanitys flaws, and so are separate from true nature and humanity... In Brave New World, true nature is constrained and separate from society; the new wild is humanitys creation; here, Savage has been rejected from the natural in the reserves, but Savage cannot cope with the demands of the new wild - London society - and so withdraws from it into what he perceives as the natural world. ...Loathsome civilised stuff! ... To sing and enjoy himself was not why he had come here; it was to escape further contamination by civilised life... However, Savage is continually confronted by the new wild beyond his attempts to escape it; so hangs himself in a final rejection of it. Characterisation is the main technique used in conveying the theme of societys overturningShow MoreRelatedA Comparison of the Themes of Blade Runner and Brave New World1480 Words   |  6 PagesA Comparison of the Themes of Blade Runner and Brave New World ‘Humanity likes to think of itself as more sophisticated than the wild yet it cannot really escape its need for the natural world’ Despite different contexts both Aldous Huxley within his book Brave New World and Ridley Scott in the film Blade Runner explore the idea that humans feel themselves more sophisticated than the natural world, yet are able to completely sever relations between humanityRead MoreMuch Ado About Nothing Key Scenes4885 Words   |  20 Pagesmarriage. Quotes from this passage: â€Å"He is of a very melancholy disposition† *Means: about Don John, always miserable â€Å"The one is too like a image and says nothing and the other is too like my lady’s eldest son, evermore tattling† *Means: Beatrice comparing Don John and Benedick â€Å"By my troth, neice, thou wilt never get thee a husband, if thou be so shrewd if thy tongue† *Means: Leonato said that if Beatrice doesn’t stop making such cutting comments she wont get a husband. â€Å"Lord, I could not endureRead MoreMarketing Mistakes and Successes175322 Words   |  702 PagesDESIGN DIRECTOR SENIOR DESIGNER SENIOR MEDIA EDITOR George Hoffman Lise Johnson Carissa Doshi Dorothy Sinclair Matt Winslow Amy Scholz Carly DeCandia Alana Filipovich Jeof Vita Arthur Medina Allison Morris This book was set in 10/12 New Caledonia by Aptara ®, Inc. and printed and bound by Courier/Westford. The cover was printed by Courier/Westford. This book is printed on acid-free paper. Copyright  © 2009, 2006, 2004, 2001, 1998, 1995, 1992, 1989, 1986, 1981, 1976 John Wiley Sons

Great Virtues free essay sample

I think that Aversion to Tyranny definitely still exists In America today. We still do not have any dictatorship In todays America. We vote as a democracy for our presidents, congress, etc. We do have a president, to represent America and to help make final decisions, but we get to choose who we want to elect. Basically, its power to the people, even though we have a presidential leader to help guide us. The second virtue Ben Franklin wanted America to have was Free Press. Basically, what this meant was that you can write or print whatever youd like and not et in trouble for it.Although there were some limits to this, there was little to no government control of the press. This let people say what they wanted and free minded write in the press. Franklin said, There would be very little printed, if publishers produced only things that offended nobody. l, myself have to agree to this, because If you think about it, its true. Franklin also believed that the surest guard against tyranny and arbitrary power was free expression, the free flow of Ideas and a free press. He felt no tyrannical society could long exist, If It cannot control the low of information and ideas.Like the first virtue, free press still exists today. You are able to freely write what youd like in the press. For example, it is okay to write to the newspapers and write a letter to the editor and express your feelings and preferences. That is legal, and no one can tell you that you arent allowed to do that. The third virtue Ben Franklin wanted America to have was Humor. Franklin liked the idea of using playful and safe humor in life. He believed that if there wasnt much humor, life would be boring and serious, and not as much fun. Franklin used moor even against himself.He created a character In Poor Richard Saunders, the pseudonym he used when he began to publish an annual almanac. The beauty of Inventing a fictional author was that he could poke fun at himself by admitting half seriously that money was his main motivation. Humor is exists in America today, as well. People use it everyday, and, to say the uses humor, it could make them laugh, no matter how upset they were. Who knows what life would be without any humor. All I know is that it would be quite dull, and this country would not be as good of a place to live in, without it.The fourth virtue Ben Franklin added to the list was Humility. When Franklin made a list of personal virtues for himself that he was intent on acquiring, he very proudly showed it around to his friends, one of whom, a Quaker, pointed out that he had left one off. The friend said that Franklin was often guilty of pride, so Ben added humility to his list. To say the least, he never quite perfected the virtue. Humility means that someone is not prideful in themselves, and not full of themselves or self-absorbed. It means that you are more modest, and dont brag.You will listen to there, and give credit; instead of listening and then start talking about yourself. Humility exists, and doesnt exist today in different ways. Sometimes, we have humility, and other times we dont. Not everyones perfect, at times we may brag or boast about ourselves a little or a lot; either way we are still not being humble. Although he was guilty of it himself, Franklin hoped that America would become more humble, and maybe it has, but whether there is a little or large amount of people not being modest, we are still breaking this virtue.The fifth virtue Ben Franklin put on the list of Americas virtues was Idealism in Foreign Policy. Franklin once wrote, The influence of every power is measured by the opinion one has of its intrinsic force. When he went to Paris as an envoy during the Revolution, Franklin proved himself a master of the diplomatic doctrine of realism by playing an adroit balance-of-power game between France, Spain, the Netherlands, and later on, Britain. The main idea of this virtue, as I see it, is that Franklin basically tried to portray each countrys position as desirable to him.In a way, this virtue still exists in America today. The only thing I can think of for this virtue in todays world is Iraq. Even though it isnt ideal to be at war with a country, we do our best to fight against them and eventually hopefully end the war and win it. The sixth virtue Ben Franklin wanted was Compromise. Franklin used the phrase, Both sides must part with some of their demands, many times. He used it the most when the Constitutional Convention was deciding on the issue of whether the new Congress should be proportioned by population or have equal votes for each state.For Franklin, who personally believed in proportional representation, compromise was not only a practical approach but also a moral one. He believed that compromisers may not be great heroes, but they do make great democracies. To compromise, it means that each side will give up one or more thing that they wanted to make it fair, since both sides couldnt get everything they wanted. In this way, it makes it fairer to compromise, than to have everything one side wants. Because, when you compromise, each side may not get everything they want, but they take a little of each side and make it even. I believe that compromising still exists in America today. Compromises are made and it exists in many different ways. America compromises with political issues and with economics also. We, as a country, compromise with other countries, when we exchange or buy products, as for how much we pay and how much products we get in exchange. The same goes for politics, not everyone can get their way, so we compromise and hopefully both sides Tolerance. The great struggles of the 20th century were against fascism and then communism.The great struggle of the 21st century will be between the forces of fanatic fundamentalism and tolerance. It is vital that we remember that America was not born with the virtue of religious tolerance, but had to earn it. For example, Franklin left Boston and ended up in Philadelphia, a place unlike much of the world. There were Lutheran, Moravian, Quakers, and even Jews living side by side in what became as the City of Brotherly Love. Franklin helped formulate the creed that they would all be better off, personally and economically, if they embraced an attitude of tolerance.So, basically, everyone had to have tolerance for other people, (and their religion) even if it wasnt of their liking, and accept their choices. I definitely think that tolerance still exists in America today. I actually think that it has gotten better. More people are accepting other peoples preferences and religions now than when Franklin was President. I think people realize that its okay to have different religions, and that you should respect others of their religious choices. I believe that the strongest virtue in America today is Humor.The reason why I think this is because I think a lot of people use humor in everyday life and its the virtue that comes the most naturally. If you think about it, America is full of humor, more than any of the other seven virtues. This is why I think it is the strongest. I think the weakest virtue in America today is Humility. There is still a lot of bragging and boasting coming from people of all ages. People will brag about anything they can think of, whether its about money or how great their Christmas lights are.Thats not what kind of country Benjamin Franklin wanted; he wanted a country that was more modest, and not as full of themselves. Im not saying that everyone in the US is like this, but some are, and its not exactly the best quality to have. The most important virtues for Americans to follow today are An Aversion to Tyranny, Compromise, and Free Press. If people didnt follow An Aversion to Tyranny, this entry could be a lot different. Its possible that we could have a different type of leader in charge and we couldnt get to choose who the leader was. If half of America decides they dont want to have a president anymore then we would really not know what to do. If people didnt follow the virtue to Compromise, it would also affect our country a lot. Without any compromising, nothing would get done and nothing would get bought. If you think about when youre buying a house or a car, if you dont compromise to get the price you want then you wont be able to purchase it. Each did has to give a little for things to work, and if neither side wanted to compromise, it would be very hard for the house or car to get sold, and for you to be able to purchase one for the price you want. Free Press, is a very important virtue for the US to have and to follow as well. Without it, I think America would be an angrier place to live, and people could possibly get in more fights because they were taking out their feelings on people instead of writing them down, to the newspaper. Even though a lot of people dont free write to the newspaper, they can still read what there people are writing to it, and see what other people are struggling with.Maybe the people who were reading the newspaper were struggling with the same issue that the person who wrote it were and that could help the person reading it with their problems as well. Ben Franklin wrote these virtues as advice for Americans, Americans today is to remember these seven virtues, and try your best to follow and respect them, as Franklin wanted. If everyone was aware of the seven virtues Ben Franklin wrote, and learned about them and truly tried their best to follow them, it could actually make a difference in this world. Maybe there would be less fighting if people were more humble and didnt brag as much.Maybe things would get done faster if people would Just take the time to compromise and work things out. We should try to be tolerant of others because if you try your best at being open-minded, it will help you become a better person, and it will help you get along with others better. If everybody tried their absolute best on all of the seven virtues that Franklin wanted for America, it really could make a difference. So, my advice to you is to follow them, and work at them everyday, and maybe one day we will have the America that Ben Franklin wanted.